Ken K.-C. Yeung
Contact Information
Title: Associate Professor, Assistant Dean (Academic, Faculty of Science)
Office: 200 NCB
Lab: G31 SDRI
Phone (Dean's Office): ext 86151
E-mail: kyeung@uwo.ca
Physical & Analytical Teaching Division
Chemical Biology and Biomaterials
Analytical and Bioanalytical Chemistry; Separations and Mass Spectrometry
Education
B.Sc., Ph.D., Calgary; NSERC PDF, Stanford and Alberta
RESEARCH
Prof. Yeung’s research focus is on the use of Matrix-Assisted Laser Desorption/Ionization mass spectrometry (MALDI MS) for tissue imaging. This technique provides a labeled-free approach to visualize the spatial distribution of the molecules of interest on biological tissue sections.
His research team’s current work focuses on tissue sample treatments that can enhance the sensitivity and selectivity of a variety molecules on brain tissues, including lipids, fatty acids and metabolites. In collaboration with researchers in the , they study how the brain chemical constituent changes due to various drug influences and neurodegeneration.
TEACHING
- 1302 - Discovering Chemical Energetics
- 9522 - Analytical Separations
SELECTED PUBLICATIONS
- Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions. De Felice, M., Chen, C., Rodríguez-Ruiz, M. et al. Neuropsychopharmacol 2022.
- Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry. Sarikahya, M. H., Cousineau, S. et al. eNeuro 28 September 2022, 9 (5) ENEURO.0253-22.2022.
- Imaging of neurotransmitters and small molecules in brain tissues using laser desorption/ionization mass spectrometry assisted with zinc oxide nanoparticles. Chen, C., Laviolette, S. R. et al. Journal of the American Society for Mass Spectrometry 2021 32 (4), 1065-1079.
- Regional Lipid Expression Abnormalities Identified Using MALDI IMS Correspond to MRI-Defined White Matter Hyperintensities within Post-mortem Human Brain Tissues. Pinsky, W., Harris, A. et al. Analytical Chemistry 2021 93 (4), 2652-2659.
- 1,6-Diphenyl-1,3,5-hexatriene (DPH) as a Novel Matrix for MALDI MS Imaging of Fatty Acids, Phospholipids, and Sulfatides in Brain Tissues. Ibrahim, H., Jurcic, K. et al. Analytical Chemistry 2017 89 (23), 12828-12836.
